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Results show that the MPA\u2010capped CdTe QDs binded to lysozyme through van der Walls forces and hydrogen bondings, causing the decrement of \u03b1\u2010helical content (\u223c7%) and increment of \u03b2\u2010sheet content (\u223c11%) of lysozyme. The binding caused static quenching of the fluorescence, while the microenvironment of aromatic amino acid residues did not show any significant alteration. The lysozyme activity was affected by the increasing exposure of QDs, it was inhibited to 53.77% under a 6\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>\u00a0M exposure compared with the control group. 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