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Some novel cyclic thioureas were synthesized, and their hCA I, hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitors and metal\u2010chelating properties were evaluated. <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values of novel synthesized compounds for AChE and BChE are in the range of 51.84\u2013135.96 and 143.96\u2013274.55 nM, respectively. Also, HCA I and II were effectively inhibited by these novel compounds, with <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values in the range of 404.16\u2013745.13 nM for hCA I and of 434.20\u2013689.57 nM for hCA II, respectively. Additionally, acetazolamide (AZA), clinically used as a CA inhibitor, with a <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> value of 883.68 \u00b1 121.27 nM in hCA I and 1008.66 \u00b1 144.70 nM in hCA II. Also, tacrine inhibited AChE and BChE showed <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values of 314.63 \u00b1 31.66 and 373.57 \u00b1 75.07 nM, respectively.<\/jats:p>","DOI":"10.1002\/jbt.21897","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T16:05:41Z","timestamp":1485273941000},"source":"Crossref","is-referenced-by-count":66,"title":["Synthesis of new cyclic thioureas and evaluation of their metal\u2010chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles"],"prefix":"10.1002","volume":"31","author":[{"given":"Parham","family":"Taslimi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  25240 Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsun","family":"Sujayev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"Garibov","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar","family":"Nazarov","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubeyir","family":"Huyut","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh H.","family":"Alwasel","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  25240 Erzurum Turkey"},{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_7_2_1","volume":"261","author":"Ilichev V. 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