{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:38Z","timestamp":1753869338955,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372497","31540061"],"award-info":[{"award-number":["31372497","31540061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or\/and aluminum (Al). Fifty\u2010two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150\u00a0mg NaF\/L) or\/and Al (300\u00a0mg AlCl<jats:sub>3<\/jats:sub>\/L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly. F induced the mottled enamel and irregular abrasion of teeth, which might occur as a consequence of depressed DSPP mRNA and DPP protein expression. Both the gene and protein expressions showed obvious decrease induced by Al, especially by F. There were no synergistic effects between F and Al, instead, Al inhibited the toxicity of F.<\/jats:p>","DOI":"10.1002\/jbt.21912","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T08:36:59Z","timestamp":1488875819000},"source":"Crossref","is-referenced-by-count":1,"title":["Fluoride or\/and aluminum induced toxicity in guinea pig teeth with the low expression of dentine phosphoprotein"],"prefix":"10.1002","volume":"31","author":[{"given":"Tianlong","family":"Han","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"},{"name":"Chifeng Academy of Agriculture and Animal Husbandry Sciences  Chifeng Inner Mongolia 024031 People's Republic of China"},{"name":"Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine Jilin University  Changchun Jilin 130062 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"},{"name":"Chifeng Academy of Agriculture and Animal Husbandry Sciences  Chifeng Inner Mongolia 024031 People's Republic of China"},{"name":"Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine Jilin University  Changchun Jilin 130062 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfang","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huacheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"},{"name":"Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine Jilin University  Changchun Jilin 130062 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Chifeng Academy of Agriculture and Animal Husbandry Sciences  Chifeng Inner Mongolia 024031 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jundong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine Shanxi Agricultural University  Taigu Shanxi 030801 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"44","volume":"1","author":"Cao J.","year":"2005","journal-title":"Fluoride"},{"key":"e_1_2_7_3_1","first-page":"67","volume":"1","author":"Poureslami H. R.","year":"2010","journal-title":"Fluoride"},{"key":"e_1_2_7_4_1","first-page":"45","volume":"1","author":"Wang M.","year":"2010","journal-title":"Fluoride"},{"key":"e_1_2_7_5_1","first-page":"1507","volume":"7","author":"Uwe K.","year":"2001","journal-title":"Environ. Toxicol. Chem"},{"key":"e_1_2_7_6_1","first-page":"5","volume":"1","author":"Choubisa S. L.","year":"2010","journal-title":"Fluoride"},{"key":"e_1_2_7_7_1","first-page":"841","volume":"10","author":"Fleming W. J.","year":"1988","journal-title":"Environ. Toxicol. Chem"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TX00288A"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2305"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0537-5"},{"key":"e_1_2_7_11_1","first-page":"1","volume":"11","author":"Niu R. Y.","year":"2015","journal-title":"Biol. Trace Elem. Res"},{"key":"e_1_2_7_12_1","first-page":"121","volume":"42","author":"Chen H. C.","year":"2009","journal-title":"Fluoride"},{"key":"e_1_2_7_13_1","first-page":"281","volume":"45","author":"Ahmad K.","year":"2012","journal-title":"Fluoride"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.12.090"},{"key":"e_1_2_7_15_1","first-page":"226","volume":"10","author":"Han T. L.","year":"2010","journal-title":"China Anim. Husband. Vet. Med"},{"key":"e_1_2_7_16_1","first-page":"19","volume":"1","author":"Han T. L.","year":"2010","journal-title":"Fluoride"},{"key":"e_1_2_7_17_1","first-page":"521","volume":"6","author":"Falk S.","year":"2015","journal-title":"Community Dent. Oral"},{"key":"e_1_2_7_18_1","first-page":"177","volume":"4","author":"Susheela A.","year":"1982","journal-title":"Fluoride"},{"key":"e_1_2_7_19_1","first-page":"75","volume":"2","author":"Pu C.","year":"1996","journal-title":"Chin. J. Control Endem. Dis"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.11.005"},{"key":"e_1_2_7_21_1","first-page":"13","volume":"1","author":"Li W. T.","year":"2007","journal-title":"Fluoride"},{"key":"e_1_2_7_22_1","first-page":"140","volume":"2","author":"Yan X. Y.","year":"2007","journal-title":"Fluoride"},{"key":"e_1_2_7_23_1","first-page":"55","volume":"07","author":"Xie Q.","year":"2005","journal-title":"Peking Univ. Med. Press"},{"key":"e_1_2_7_24_1","first-page":"56","volume":"1","author":"Luo S.","year":"2003","journal-title":"Chin. J. Stomatol"},{"key":"e_1_2_7_25_1","first-page":"74","volume":"27","author":"Sreenath T.","year":"2003","journal-title":"J. Biol. Chem"},{"key":"e_1_2_7_26_1","first-page":"542","volume":"7","author":"Izabela M.","year":"2012","journal-title":"J. Dent"},{"key":"e_1_2_7_27_1","first-page":"583","volume":"3","author":"Barbara S.","year":"2015","journal-title":"Dent. Clin. North Am"},{"key":"e_1_2_7_28_1","first-page":"228","volume":"3","author":"Sina D.","year":"2009","journal-title":"Fluoride"},{"key":"e_1_2_7_29_1","first-page":"10","volume":"13","author":"Sankha K.","year":"2016","journal-title":"J. Hazard. Mater"},{"key":"e_1_2_7_30_1","first-page":"199","volume":"3","author":"Mario R.","year":"2011","journal-title":"Cell Biol. Toxicol"},{"key":"e_1_2_7_31_1","first-page":"351","volume":"4","author":"Pooja K.","year":"2011","journal-title":"Neurotox. Res"},{"key":"e_1_2_7_32_1","first-page":"847","volume":"4","author":"Omar M.","year":"2015","journal-title":"Comp. Clin. Pathol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-015-1846-9"},{"key":"e_1_2_7_34_1","first-page":"109","volume":"2","author":"Chinoy N.","year":"2005","journal-title":"Fluoride"},{"key":"e_1_2_7_35_1","article-title":"Research progress on the joint effect of fluoride and aluminium","author":"Li H.","year":"2005","journal-title":"Global Conference of Geographers Abstract"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.12.064"},{"key":"e_1_2_7_37_1","first-page":"99","volume-title":"Springer\u2010Verlag Berlin Heidelberg","author":"Niinomi M.","year":"2015"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.835"},{"key":"e_1_2_7_39_1","first-page":"177","volume":"1","author":"Wang J.","year":"2003","journal-title":"Fluoride"},{"key":"e_1_2_7_40_1","first-page":"112","volume":"2","author":"Hao Y.","year":"2003","journal-title":"Chin. J. Conserv. Dent"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900609"},{"key":"e_1_2_7_42_1","first-page":"191","volume":"6","author":"Yukiko N.","year":"2014","journal-title":"Dent. Pulp"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0057"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.04.013"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.04.092"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.03.161"},{"key":"e_1_2_7_47_1","first-page":"33","volume":"1","author":"Chen R. A.","year":"1995","journal-title":"Ind. Health Occup. Dis"},{"key":"e_1_2_7_48_1","first-page":"172","volume":"3","author":"Hua W.","year":"2001","journal-title":"J. Xianning Med. College"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:37:20Z","timestamp":1696358240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/jbt.21912"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21912","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"type":"print","value":"1095-6670"},{"type":"electronic","value":"1099-0461"}],"subject":[],"published":{"date-parts":[[2017,3,7]]},"article-number":"e21912"}}