{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:54:33Z","timestamp":1782968073973,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007350","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["153377"],"award-info":[{"award-number":["153377"]}],"id":[{"id":"10.13039\/501100007350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>UbcH7 is an ubiquitin\u2010conjugating enzyme that interacts with parkin, an E3 ligase. The UbcH7\u2013parkin complex promotes the ubiquitination and degradation of several proteins via the 26S proteasome. Cellular accumulation of the UbcH7\u2013parkin targets alpha\u2010synuclein and synphilin\u20101 has been associated with Parkinson disease. In mouse liver, 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin, an aryl hydrocarbon receptor ligand, induces UbcH7 expression. Therefore, the aim of the present study was to determine whether 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin induces<jats:italic>Ubch7<\/jats:italic>mRNA and UbcH7 protein expression in the mouse brain, to characterize the molecular mechanism, and the effect on synphilin\u20101 half\u2010life. We found that 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin promotes the aryl hydrocarbon receptor binding to<jats:italic>Ubch7<\/jats:italic>gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata. In parallel, 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin promoted synphilin\u20101 degradation in an aryl hydrocarbon receptor\u2010dependent way.<\/jats:p>","DOI":"10.1002\/jbt.21947","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T14:56:42Z","timestamp":1497625002000},"source":"Crossref","is-referenced-by-count":14,"title":["TCDD induces UbcH7 expression and synphilin\u20101 protein degradation in the mouse ventral midbrain"],"prefix":"10.1002","volume":"31","author":[{"given":"Emmanuel","family":"Gonz\u00e1lez\u2010Barbosa","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular CINVESTAV\u2010IPN M\u00e9xico D.F M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mej\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular CINVESTAV\u2010IPN M\u00e9xico D.F M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Bautista","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Biof\u00edsica y Neurociencias CINVESTAV\u2010IPN M\u00e9xico D.F M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, NCI National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Segovia","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Biof\u00edsica y Neurociencias CINVESTAV\u2010IPN M\u00e9xico D.F M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-9126","authenticated-orcid":false,"given":"Guillermo","family":"Elizondo","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular CINVESTAV\u2010IPN M\u00e9xico D.F M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.34.040194.002015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400004200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190256997"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7732381"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.10.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06880"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12130"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.12.029"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.10.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0026-895X(24)26518-4","volume":"57","author":"Elizondo G.","year":"2000","journal-title":"Mol. 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