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Rats were subjected to oral pretreatment of CR (25 and 50\u00a0mg\/kg b.w.) via feeding needle for 6 days against hepatotoxicity induced by a single dose of PC (500\u00a0mg\/kg b.w.) administered orally via feeding needles. Although PC increases lipid peroxidation and liver enzyme activities, it has led to reduction of antioxidant enzyme activities. PC induced inflammatory responses by increasing the levels of TNF\u2010\u03b1 and IL\u20101\u03b2. Furthermore, PC caused apoptosis and autophagy by increasing activity of Caspase\u20103 and LC3B level. On the other hand, CR therapy significantly regulated these values in rats. This study demonstrated that CR possesses restorative effect against PC\u2010induced hepatotoxicity by suppressing oxidative stress, inflammation, and apoptotic and autophagic tissue damage.<\/jats:p>","DOI":"10.1002\/jbt.21960","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T14:58:31Z","timestamp":1499353111000},"source":"Crossref","is-referenced-by-count":77,"title":["Restorative effects of Chrysin pretreatment on oxidant\u2013antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol\u2010induced hepatotoxicity in rats: An experimental and biochemical study"],"prefix":"10.1002","volume":"31","author":[{"given":"Eyup","family":"Eldutar","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty, of Veterinary Medicine Ataturk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-2479","authenticated-orcid":false,"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty, of Veterinary Medicine Ataturk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"Kucukler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty, of Veterinary Medicine Ataturk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuneyt","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Bingol University  Bingol 12000 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5350"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i19.2448"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2007.02.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.12.1499"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2015.09.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12501"},{"key":"e_1_2_6_8_1","author":"Hohmann M. 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