{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:07:48Z","timestamp":1761311268599,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The diagnosis of acute kidney injury (AKI) is frequently established on modifications in serum creatinine (SCr). The discriminative and prognostic aptitudes of serum cystatin\u2010C as well as N\u2010acetylglucosaminidase (NAG) and Interleukin\u201018 (IL\u201018) were inspected for the estimation of AKI.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>In this study twelve rats were alienated into two groups: control group received saline, second group received cadmium chloride at a dose (2.4\u00a0mg Cd\/kg\/day, i.p) for 30 days. Blood urea nitrogen (BUN), SCr, and IL\u201018 serum level were measured in addition to serum and tissue content of cystatin\u2010C and NAG.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>AKI model showed significant increase in BUN, creatinine, and IL\u201018. RT\u2010PCR showed upregulation of cystatin\u2010C gene besides significant increase of its level in serum. Additionally, tissue content of NAG was significantly increased.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Our findings may provide that grouping of several biomarkers for diagnosis of AKI is a more valuable diagnostic tool than single\u2010marker measurement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbt.21968","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T17:08:46Z","timestamp":1501520926000},"source":"Crossref","is-referenced-by-count":7,"title":["Relevance of cystatin\u2010C, N\u2010acetylglucosaminidase, and Interleukin\u201018 with the diagnosis of acute kidney injury induced by cadmium in rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Ola Sayed","family":"Mohamed Ali","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy (Girls) Al Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-8913","authenticated-orcid":false,"given":"Shereen Saeid","family":"Elshaer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy (Girls) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-7126","authenticated-orcid":false,"given":"Hend Mohamed","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry National Organization for Drug Control and Research  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamdouh Salah EL\u2010din","family":"Zohni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry National Organization for Drug Control &amp; Research  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854070"},{"key":"e_1_2_7_3_1","first-page":"15","volume":"8","author":"Firu S. 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