{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:35:26Z","timestamp":1792074926397,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal toxicity is one of the most severe complications that can occur with cisplatin (CIS) administration in cancer patients. Montelukast (ML) renoprotective outcome contrary to CIS\u2010drawn nephrotoxicity remains obscure. Therefore, adult male Sprague\u2013Dawley rats were orally given ML (10 and 20\u00a0mg\/kg\/day) 5 days before and after single CIS (5\u00a0mg\/kg; i.p.) treatment. ML returned blood urea nitrogen, as well as serum creatinine and gamma glutamyl transferase that were elevated by CIS to normal level. The improved kidney function tests corroborated the attenuation of CIS renal injury at the microscopical level. It also reduced serum\/renal nitric oxide and renal hemeoxygenase\u20101. Meanwhile, ML hindered the raised levels of serum endothelin\u20101, serum and renal tumor necrosis factor\u2010\u03b1, and monocyte chemoattractant protein\u20101. These effects were associated by deceased caspase\u20103 expression in kidney after ML treatment. In conclusion, ML guards against CIS\u2010induced nephrotoxicity via anti\u2010inflammatory and antiapoptotic properties.<\/jats:p>","DOI":"10.1002\/jbt.21979","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T13:14:53Z","timestamp":1505308493000},"source":"Crossref","is-referenced-by-count":18,"title":["Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-184X","authenticated-orcid":false,"given":"Amany M.","family":"Gad","sequence":"first","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola M. Abd","family":"El\u2010Raouf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahia M.","family":"El\u2010Sayeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalaal M.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"178","volume-title":"The Encyclopedia of Allergies","author":"Lipkowitz M. A.","year":"2001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-009-0038-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2008.04.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61326-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02963.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.mar-2"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"197","volume":"6","author":"Mahir I.","year":"2012","journal-title":"Afr. J. Microbiol. Res."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90331-T"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"184","volume":"3","author":"Viradia U. M.","year":"2011","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"issue":"3","key":"e_1_2_8_11_1","first-page":"455","volume":"58","author":"Holma R.","year":"2007","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.11.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs312"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.07.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.03.018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00996.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-013-0949-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.647305"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.S1.S170"},{"key":"e_1_2_8_20_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute of Laboratory Animal Resources","year":"1996"},{"issue":"4","key":"e_1_2_8_21_1","first-page":"248","volume":"34","author":"Erdinc M.","year":"2007","journal-title":"Dicle T\u0131p Dergisi"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.122"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0319"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.414"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.10.019"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00303.2002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.4.L659"},{"issue":"10","key":"e_1_2_8_28_1","first-page":"617","volume":"23","author":"Chen A.","year":"2000","journal-title":"Chin. J. Tubercul. Respir. Dis."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.08.006"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1375"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43302"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01673.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70504-7"},{"issue":"3","key":"e_1_2_8_34_1","first-page":"54","volume":"2","author":"Ferrari C. K. B.","year":"2011","journal-title":"Res. World J. Arts Sci. Comer."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid577.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.105616"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199907000-00068"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3891"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2007000800007"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101999"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000015609.31253.7F"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0027"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11337"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02323.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.05.007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033453749"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015957026924"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2012.09.002"},{"key":"e_1_2_8_49_1","first-page":"870","volume":"26","author":"Wang Q.","year":"2012","journal-title":"FASEB J."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20130052"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00395-8"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007059"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.02.007"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.21979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.21979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:17:21Z","timestamp":1696004241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.21979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jbt.21979"],"URL":"https:\/\/doi.org\/10.1002\/jbt.21979","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,13]]},"article-number":"e21979"}}