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Treatment was carried out by administration of SIM (20\u00a0mg\/kg\/day; p.o.) or CARV (50\u00a0mg\/kg\/day; p.o.) or combination of them. Treatment with CARV significantly decreased total cholesterol, triglycerides, low\u2010density lipoprotein, atherogenic index, leptin, and increased high\u2010density lipoprotein and adiponectin. Moreover, CARV potentiated the hypolipidemic effect of SIM. Both SIM and CARV alleviated the oxidative stress induced by P407. Interestingly, CARV, when combined with SIM, significantly ameliorated SIM\u2010induced liver and muscle injury by reducing the level of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine kinase, and myoglobin and restoring the normal histological picture of both liver and muscle as well as apoptosis.<\/jats:p>","DOI":"10.1002\/jbt.21981","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T08:50:42Z","timestamp":1509007842000},"source":"Crossref","is-referenced-by-count":21,"title":["Combination of carvacrol with simvastatin improves the lipid\u2010lowering efficacy and alleviates simvastatin side effects"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-3803","authenticated-orcid":false,"given":"Hayat A.","family":"Abd El Aal","sequence":"first","affiliation":[{"name":"Department of Pharmacology, National Organization for Drug Control and Research NODCAR  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiaa A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wedad A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National Organization for Drug Control and Research NODCAR  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National Organization for Drug Control and Research NODCAR  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmy","family":"Moawad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2012.11.003"},{"issue":"09","key":"e_1_2_7_3_1","first-page":"605","volume":"53","author":"Klotz U.","year":"2003","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00372"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S11244"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02969-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00437-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02970-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i6.184"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"219","volume":"2","author":"Rahman K.","year":"2007","journal-title":"Clin. 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