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In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), \u03b1\u2010glucosidase (\u03b1\u2010Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of \u03b1\u2010glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 3.70\u00a0\u00b1\u00a00.92\u201379.66\u00a0\u00b1\u00a020.81\u00a0nM against hCA I, 2.98\u00a0\u00b1\u00a00.33\u201384.88\u00a0\u00b1\u00a040.32\u00a0nM against hCA II, 4.93\u00a0\u00b1\u00a02.01\u2013593.60\u00a0\u00b1\u00a0134.74\u00a0nM against \u03b1\u2010Gly, 0.52\u00a0\u00b1\u00a00.18\u201346.80\u00a0\u00b1\u00a017.15\u00a0nM against AChE, and 1.25\u00a0\u00b1\u00a00.22\u201332.08\u00a0\u00b1\u00a02.68 against BChE.<\/jats:p>","DOI":"10.1002\/jbt.21995","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T13:14:54Z","timestamp":1505308494000},"source":"Crossref","is-referenced-by-count":150,"title":["The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and \u03b1\u2010glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ataturk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-554X","authenticated-orcid":false,"given":"Cuneyt","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Bingol University  Bingol 12000 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ataturk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0774-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.09.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.03.031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1168438"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02142.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2009.07.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5040038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2009.12.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.05.053"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.604318"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.0197"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.09.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i28.3824"},{"key":"e_1_2_7_15_1","first-page":"93","volume":"40","author":"Zeytinoglu M.","year":"1998","journal-title":"Acta Pharm. 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