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Carbonic anhydrase (CA, E.C.4.2.1.1), a metalloenzyme familly, catalyzes the interconversion of these ions (CO<jats:sub>2<\/jats:sub> and HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>) and are very common in living organisms. In this study, a series of novel 2\u2010amino\u20103\u2010cyanopyridines supported with some functional groups was synthesized and tested as potential inhibition effects against both cytosolic human CA I and II isoenzymes (hCA I and II) using by Sepharose\u20104B\u2010<jats:sc>l<\/jats:sc>\u2010tyrosine\u2010sulfanilamide affinity chromatography. The structural elucidations of novel 2\u2010amino\u20103\u2010cyanopyridines were achieved by NMR, IR, and elemental analyses. <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of the novel synthesized compounds were found in range of 2.84\u2013112.44\u00a0\u03bcM against hCA I and 2.56\u201331.17\u00a0\u03bcM against hCA II isoenzyme. While compound <jats:bold>7d<\/jats:bold> showed the best inhibition activity against hCA I (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 2.84\u00a0\u03bcM), the compound <jats:bold>7b<\/jats:bold> demonstrated the best inhibition profile against hCA II isoenzyme (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 2.56\u00a0\u03bcM).<\/jats:p>","DOI":"10.1002\/jbt.21998","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T13:16:37Z","timestamp":1505308597000},"source":"Crossref","is-referenced-by-count":24,"title":["Synthesis of 2\u2010amino\u20103\u2010cyanopyridine derivatives and investigation of their carbonic anhydrase inhibition effects"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-4143","authenticated-orcid":false,"given":"Aliye","family":"Altundas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts Gazi University  Ankara 06500 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts Gazi University  Ankara 06500 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u00c7ankaya","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Arts Erzincan University  Erzincan 24100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Atasever","sequence":"additional","affiliation":[{"name":"Department of Food Science, Ispir H. 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