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The novel <jats:italic>N<\/jats:italic>\u2010propylphthalimide\u2010substituted and 4\u2010vinylbenzyl\u2010substituted NHC precursors have been characterized by using <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 351.0\u20131269.9\u00a0nM against hCA I, 346.6\u20131193.1\u00a0nM against hCA II, and 19.0\u201376.3\u00a0nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 1246.7\u00a0nM against hCA I and 1407.6\u00a0nM against hCA II. Additionally, tacrine inhibited AChE and obtained a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 174.6\u00a0nM.<\/jats:p>","DOI":"10.1002\/jbt.22009","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T14:04:40Z","timestamp":1510927480000},"source":"Crossref","is-referenced-by-count":70,"title":["Novel <i>N<\/i>\u2010propylphthalimide\u2010 and 4\u2010vinylbenzyl\u2010substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes"],"prefix":"10.1002","volume":"32","author":[{"given":"Yakup","family":"Sar\u0131","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences In\u00f6n\u00fc University  Malatya 44280 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayd\u0131n","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences In\u00f6n\u00fc University  Malatya 44280 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetkin","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences In\u00f6n\u00fc University  Malatya 44280 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200603380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068372z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200301714"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.3116"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1304-72"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/22243682.2014.882795"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2016.05.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1132210"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1156102"},{"key":"e_1_2_7_11_1","first-page":"821","volume":"46","author":"Cetinkaya B.","year":"1996","journal-title":"Drug Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejmech.2014.11.005","volume":"90","author":"Haque R. 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