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Carbonic anhydrase (CA, E.C. 4.2.1.1) is a zinc\u2010containing metalloenzyme that catalyzes the reversible hydration of carbon dioxide (CO<jats:sub>2<\/jats:sub>) to yield protons (H<jats:sup>+<\/jats:sup>) and bicarbonate (HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>). In this study, some avermectins, including abamectin, doramectin, eprinomectin, and moxidectin, were investigated for <jats:italic>in vitro<\/jats:italic> inhibitory effects on the CA enzyme purified from goat liver, which was purified (125.00\u2010fold) using sepharose 4B\u2010<jats:sc>l<\/jats:sc>\u2010tyrosine\u2010sulfanilamide affinity chromatography, with a yield of 68.27% and a specific activity of 21765.31\u00a0EU\/mg proteins. The inhibition results obtained from this study showed <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of 0.283, 0.153, 0.232, and 0.317\u00a0nM for abamectin, doramectin, eprinomectin, and moxidectin, respectively. On the other hand, acetazolamide, well\u2010known clinically established CA inhibitor, possessed a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 0.707\u00a0nM against goat liver CA.<\/jats:p>","DOI":"10.1002\/jbt.22010","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T14:06:45Z","timestamp":1510582005000},"source":"Crossref","is-referenced-by-count":48,"title":["The toxicological effects of some avermectins on goat liver carbonic anhydrase enzyme"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-554X","authenticated-orcid":false,"given":"Cuneyt","family":"Caglayan","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine, Bing\u00f6l University  Bing\u00f6l 12000 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21938"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1403-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1368019"},{"key":"e_1_2_7_5_1","author":"Taslimi P.","year":"2017","journal-title":"J. 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