{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:14:04Z","timestamp":1776730444734,"version":"3.51.2"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study evaluates the protective effect of \u03b1\u2010lipoic acid (LA) against arsenic\u2010induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sperm viability, and sperm membrane integrity. Significant reduction in the activity levels of superoxide dismutase, catalase, and glutathione levels with a concomitant increase in the lipid peroxidation and protein carbonyl content in the testis and the cauda epididymis of arsenic\u2010exposed rats. Arsenic intoxication also enhanced the testicular caspase\u20103 mRNA levels, disorganization of testicular and cauda epididymal architecture as well as increased arsenic content in the testis and the cauda epididymis of rats. Arsenic exposure also deteriorated fertility ability in male rats over controls. Conversely, \u03b1\u2010LA negated the testicular and cauda epididymal oxidative stress and restored the male reproductive health in arsenic\u2010exposed rats.<\/jats:p>","DOI":"10.1002\/jbt.22016","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T08:32:52Z","timestamp":1512635572000},"source":"Crossref","is-referenced-by-count":30,"title":["\u03b1\u2010Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic\u2010intoxicated rats"],"prefix":"10.1002","volume":"32","author":[{"given":"Papisetty","family":"Prathima","sequence":"first","affiliation":[{"name":"Department of Biotechnology Vikrama Simhapuri University  Nellore AP 524003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanadhapuram","family":"Pavani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Vikrama Simhapuri University  Nellore AP 524003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadepalli","family":"Sukeerthi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Vikrama Simhapuri University  Nellore AP 524003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-776X","authenticated-orcid":false,"given":"Sri Bhashyam","family":"Sainath","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Vikrama Simhapuri University  Nellore AP 524003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr184"},{"key":"e_1_2_6_3_1","first-page":"257","volume":"51","author":"Flora S. J. S.","year":"2011","journal-title":"Biol. Med"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.022"},{"key":"e_1_2_6_5_1","first-page":"8843","volume":"47","author":"Shen H.","year":"2013","journal-title":"Environ. Sci. Technol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1289\/ehp.00108847","volume":"108","author":"Tseng C. H.","year":"2000","journal-title":"Environ. Health Perspect"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10423"},{"key":"e_1_2_6_8_1","first-page":"27","volume":"5","author":"Sarkar M.","year":"2003","journal-title":"Asian J. Androl"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016686113763"},{"key":"e_1_2_6_10_1","first-page":"287","volume":"15","author":"Ahmad I.","year":"2008","journal-title":"Prof. Med. J."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2015.19.4.167"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2011.08.145"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100008X259169"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300015c"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713512891"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12561"},{"key":"e_1_2_6_17_1","first-page":"570","volume":"57","author":"Bilska A.","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.07.001"},{"key":"e_1_2_6_19_1","first-page":"875","volume":"29","author":"El\u2010Bishbishy H. A.","year":"2013","journal-title":"Environ. Occup. Health"},{"key":"e_1_2_6_20_1","first-page":"451","volume":"57","author":"Gules O.","year":"2016","journal-title":"Rom. J. Morphol. Embryol"},{"key":"e_1_2_6_21_1","first-page":"105","volume":"49","author":"Hamdy B. G.","year":"2016","journal-title":"Alexa J. Vet. Sci"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2017.06.009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2010.538751"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.10.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.05.018"},{"key":"e_1_2_6_26_1","first-page":"257","volume":"35","author":"CPCSEA (Committee for the Purpose of control and supervision on experiments on animals)","year":"2003","journal-title":"Indian J. Pharmacol."},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","DOI":"10.1201\/b17359","volume-title":"Principles and Method of Toxicology","author":"Hayes W.","year":"2014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2012.04.018"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32518"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_2_6_31_1","first-page":"976","volume":"70","author":"Mandal B. K.","year":"1996","journal-title":"Curr. Sci"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9558-7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0540103"},{"key":"e_1_2_6_34_1","author":"Belsey M. A.","year":"1980","journal-title":"Press Concern"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402150210"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019208987714"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(92)90034-Q"},{"key":"e_1_2_6_38_1","first-page":"447","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer H. U.","year":"1974"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45228-9"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(55)02300-8"},{"key":"e_1_2_6_41_1","first-page":"8","volume-title":"Red Cell Metabolism: A Manual of Biochemical Methods","author":"Beutler E.","year":"1975"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_6_45_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0076-6879(57)03493-X","volume":"3","author":"Ballentine R.","year":"1957","journal-title":"Methods Enzymol."},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2011.04.005"},{"key":"e_1_2_6_47_1","first-page":"199","volume":"20","author":"Mosadegh M.","year":"2017","journal-title":"Iran. J. Med. Sci"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2017.1376405"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2012-0039"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht467oa"},{"key":"e_1_2_6_51_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/19396368.2014.998350","volume":"61","author":"Jahan S.","year":"2015","journal-title":"Syst. Biol. Reprod. Biol"},{"key":"e_1_2_6_52_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/and.12472","volume":"48","author":"Ince S.","year":"2015","journal-title":"Andrologia"},{"key":"e_1_2_6_53_1","first-page":"2000","volume-title":"Madame Curie Bioscience Database","author":"Aitken R. J."},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-126"},{"key":"e_1_2_6_55_1","first-page":"357","volume":"129","author":"Makker K.","year":"2009","journal-title":"Indian J. Med. Res"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.07.026"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769109105221"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12403-009-0013-8"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90306-P"},{"key":"e_1_2_6_60_1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","volume":"1830","author":"Shelly C.","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_6_61_1","first-page":"a008656","volume":"5","author":"Mc Ilwain D. R.","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"e_1_2_6_62_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1515\/znc-2015-5031","volume":"70","author":"Fouad A. A.","year":"2015","journal-title":"Z. Naturforsch. C"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2014.26.208-212"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040322"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20354"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T12:12:51Z","timestamp":1695816771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jbt.22016"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22016","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"article-number":"e22016"}}