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CCl<jats:sub>4<\/jats:sub> administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl<jats:sub>4<\/jats:sub> produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase\u20101 expression, antioxidant defenses, and accumulation of 4\u2010hydroxynonenal and 3\u2010nitrotyrosine. Furthermore, CCl<jats:sub>4<\/jats:sub> administration evoked profound expression of pro\u2010inflammatory cytokine expressions such as tumor necrosis factor\u2010\u03b1, monocyte chemoattractant protein\u20101, and interleukin\u20101\u03b2 in hepatic tissues, which corroborated with nuclear factor \u03baB activation. Additionally, CCl<jats:sub>4<\/jats:sub>\u2010treated animals exhibited higher apoptosis, characterized by increased caspase 3 activity, DNA fragmentation, and poly (ADP\u2010ribose) polymerase activation. Moreover, histological and biochemical investigations revealed marked fibrosis in the livers of CCl<jats:sub>4<\/jats:sub>\u2010administered animals. However, NTK treatment mitigated CCl<jats:sub>4<\/jats:sub>\u2010induced phenotypic changes. In conclusion, our findings suggest that NTK exerts hepatoprotective and anti\u2010fibrotic actions by suppressing oxidative stress, inflammation, and apoptosis.<\/jats:p>","DOI":"10.1002\/jbt.22017","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T08:34:46Z","timestamp":1512635686000},"source":"Crossref","is-referenced-by-count":42,"title":["Nootkatone confers hepatoprotective and anti\u2010fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis"],"prefix":"10.1002","volume":"32","author":[{"given":"Amani","family":"Kurdi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics Beirut Arab University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences United Arab Emirates University  Al Ain 17666 United Arab Emirates"},{"name":"Department of Basic Sciences College of Medicine and Health Sciences, Mohammed Bin Rashid University of Medicine and Health Sciences  Dubai 505055 United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences United Arab Emirates University  Al Ain 17666 United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-2184","authenticated-orcid":false,"given":"Mohanraj","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences United Arab Emirates University  Al Ain 17666 United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02264.x"},{"issue":"20","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.2174\/1381612822666160322145255","volume":"22","author":"Ojha S.","year":"2016","journal-title":"Curr. 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