{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:04:16Z","timestamp":1788498256168,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb\u2010induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500\u00a0mg\/kg body weight\/day) or forskolin (5\u00a0mg\/kg body weight\/day) or both for 65 days and analyzed for spermatogenesis and steroidogenesis and testicular and epididymal oxidative toxicity. A significant decrease in daily sperm production, epididymal sperm count, motile, viable, and hypo\u2010osmotic swelling\u2010tail swelled sperm was observed in mancozeb\u2010treated rats. The activity levels of testicular 3\u03b2\u2010hydroxysteroid dehydrogenase and 17\u03b2\u2010hydroxysteroid dehydrogenase and circulatory testosterone levels were significantly decreased in mancozeb\u2010treated rats. Exposure to mancozeb resulted in a significant decrease in glutathione levels and superoxide dismutase and catalase activity levels with an increase in lipid peroxidation levels in the testes and epididymis. Coadministration of forskolin mitigated the mancozeb\u2010induced oxidative toxicity and suppressed steroidogenesis and spermatogenesis.<\/jats:p>","DOI":"10.1002\/jbt.22026","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T13:09:21Z","timestamp":1514466561000},"source":"Crossref","is-referenced-by-count":22,"title":["Forskolin ameliorates mancozeb\u2010induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis"],"prefix":"10.1002","volume":"32","author":[{"given":"B.P.","family":"Girish","sequence":"first","affiliation":[{"name":"Department of Biotechnology S.V. University  Tirupati 517 502 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-719X","authenticated-orcid":false,"given":"P. Sreenivasula","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Zoology S.V. 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