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The results indicated that the individual exposure to TCS evoked a significant decline in T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> but the levels of estradiol, FSH, and LH were significantly elevated beside marked up regulation of calbindin\u2010D9k and estrogen \u03b1 mRNA expression. On the other hand, the single exposure to NaF causes insignificant changes in thyroid hormones, but evoked a trend toward an increase in both estradiol and LH levels. No significant differences in the TSH level were recorded among the experimental groups. The joint exposure to TCS and NaF induced a significant improvement in thyroid and reproductive hormone levels. Overall, these findings revealed that exposure to TCS resulted in significant endocrine and reproductive alterations in immature female rats, while TCS\u00a0+\u00a0NaF coexposure resulted in lessening most effects.<\/jats:p>","DOI":"10.1002\/jbt.22027","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T14:16:15Z","timestamp":1515680175000},"source":"Crossref","is-referenced-by-count":16,"title":["Impact of subchronic exposure to triclosan and\/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin\u2010D9k and estrogen receptor \u03b1 genes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-6385","authenticated-orcid":false,"given":"Yasmina M.","family":"Abd\u2010Elhakim","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine Zagazig University  Zagazig 44511 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany T.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine Zagazig University  Zagazig 44511 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Zagazig University  Zagazig 44511 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.04.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.04.010"},{"key":"e_1_2_6_4_1","volume":"7","author":"Cao X.","year":"2017","journal-title":"Sci. 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