{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:20:43Z","timestamp":1767896443546,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rutin, naturally occurring flavonoid, has reported to cover interesting multiple pharmacological properties. This study evaluated rutin or\/and meloxicam effects in paw inflammation induced by formalin in mice. Mice were divided into four groups: I\u2010Formalin group, II\u2010Rutin 60\u00a0mg\/kg (p.o.), III\u2010Meloxicam 10\u00a0mg\/kg (p.o.), plus IV\u2010Combined rutin and meloxicam. Therapies were administered once a day for 7 days. The curative effects were assessed on inflammatory, oxidative stress, and apoptosis. Both rutin and\/or meloxicam induced marked improvement in paw licking time on the 1st day and by combined treatment only on the 3rd day as well reduction in paw edema% on the 3rd day. Moreover, noticeable progress in liver malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities as well decline in paw interleukin\u20101\u03b2 level and extent of apoptosis. The results spot light on the good influence of combined rutin and meloxicam in formalin\u2010induced mice paw inflammation to a better extent than either rutin or meloxicam lonely.<\/jats:p>","DOI":"10.1002\/jbt.22029","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:54:26Z","timestamp":1515545666000},"source":"Crossref","is-referenced-by-count":19,"title":["Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-3523","authenticated-orcid":false,"given":"Ebtehal M.","family":"Fikry","sequence":"first","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research, NODCAR  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wedad A.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research, NODCAR  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman G.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Molecular Evaluation National Organization for Drug Control and Research, NODCAR  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"5498054","DOI":"10.1155\/2017\/5498054","volume":"2017","author":"Anilkumar K.","year":"2017","journal-title":"Oxid. 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