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Novel <jats:italic>N<\/jats:italic>\u2010bis\u2010cyanomethylamine and alkoxymethylamine derivatives were effective inhibitors of the \u03b1\u2010glycosidase, cytosolic carbonic anhydrase I and II isoforms, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values in the range of 0.15\u201313.31\u00a0nM for \u03b1\u2010glycosidase, 2.77\u201315.30\u00a0nM for human carbonic anhydrase isoenzymes I (hCA I), 3.12\u201321.90\u00a0nM for human carbonic anhydrase isoenzymes II (hCA II), 23.33\u201373.23\u00a0nM for AChE, and 3.84\u201348.41\u00a0nM for BChE, respectively. Indeed, the inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances.<\/jats:p>","DOI":"10.1002\/jbt.22042","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T17:14:56Z","timestamp":1519233296000},"source":"Crossref","is-referenced-by-count":78,"title":["Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and \u03b1\u2010glycosidase enzymes inhibitors: The novel <i>N<\/i>,<i>N<\/i>\u2032\u2010bis\u2010cyanomethylamine and alkoxymethylamine derivatives"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-554X","authenticated-orcid":false,"given":"Cuneyt","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Bingol University  Bingol Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagif","family":"Farzaliyev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oruj","family":"Nabiyev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsun","family":"Sujayev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives Azerbaijan National Academy of Sciences  Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-3157","authenticated-orcid":false,"given":"Fikret","family":"Turkan","sequence":"additional","affiliation":[{"name":"Health Services Vocational School Igd\u0131r University  Igd\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruya","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  Erzurum Turkey"},{"name":"Agri Ibrahim Cecen University Central Research and Application Laboratory  Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1238367"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201100272"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201400257"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190710103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.52.2004.4.4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.10.024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360310001656736"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.2257"},{"key":"e_1_2_7_11_1","first-page":"441","volume":"31","author":"Gocer H.","year":"2016","journal-title":"J. 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