{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:04:59Z","timestamp":1772269499710,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472028"],"award-info":[{"award-number":["81472028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Based on miR\u2010874 expression levels in the GSE47841 microarray, we hypothesized that the mature products of miR\u2010874, miR\u2010874\u20103p, or miR\u2010874\u20105p, would inhibit epithelial ovarian cancer (EOC) cell proliferation, metastasis, and chemoresistance. We first examined miR\u2010874\u20103p and miR\u2010874\u20105p expression levels in primary EOC tumor tissue samples and found that they were significantly decreased. 3\u2010(4,5\u2010Dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyl tetrazolium bromide (MTT) cell proliferation and transwell assays revealed that miR\u2010874\u20103p and miR\u2010874\u20105p significantly inhibit EOC cell proliferation, migration, and invasion. Then, using MTT and soft agar assays of paclitaxel\u2010treated Caov3 and SKOV3 cells transfected with miR\u2010874\u20103p and miR\u2010874\u20105p, we found that miR\u2010874\u20103p and miR\u2010874\u20105p enhance EOC cell chemosensitivity. We then confirmed that serine\/threonine\u2010protein kinase 2 (SIK2) was a target gene of miR\u2010874\u20103p and miR\u2010874\u20105p. Overall, the results of this study indicate that SIK2 expression can serve as a prognostic biomarker for EOC and that miR\u2010874\u20103p and miR\u2010874\u20105p have the potential to enhance clinical treatment of EOC.<\/jats:p>","DOI":"10.1002\/jbt.22168","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T14:01:53Z","timestamp":1531490513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Upregulation of miR\u2010874\u20103p and miR\u2010874\u20105p inhibits epithelial ovarian cancer malignancy via SIK2"],"prefix":"10.1002","volume":"32","author":[{"given":"Bairong","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Gynecology Harbin Medical University Cancer Hospital  Harbin 150020 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology Harbin 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