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So, this investigation was assessed to evaluate the nephrotoxic potential of SVP and the defensive impact of CAFF against SVP nephrotoxicity. SVP was given at a dose of 500 mg\/kg (i.p.) once daily for 2 weeks, while CAFF was given at a dose of 50 mg\/kg (orally), simultaneously with SVP. Concurrent treatment with CAFF reduced urea and creatinine, lipid peroxidation (malondialdehyde), tumor necrosis factor alpha (TNF\u2010\u03b1), interferon gamma (IFN\u2010\u03b3), nuclear factor kappa B (NF\u2010\u03baB\/p65), and transforming growth factor \u03b2 (TGF\u2010\u03b2) levels. However, with increased glutathione content, CAFF also halted the activated Notch signaling cascade. Furthermore, CAFF suppressed caspase\u20103 and inducible nitric oxide synthase expressions. To conclude, on the basis of the results obtained, CAFF proved to protect against SVP\u2010induced nephrotoxicity via its antioxidant, anti\u2010inflammatory, and antiapoptotic properties.<\/jats:p>","DOI":"10.1002\/jbt.22175","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T11:34:16Z","timestamp":1530617656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Study on the influence of caffeic acid against sodium valproate\u2013induced nephrotoxicity in rats"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-184X","authenticated-orcid":false,"given":"Amany M.","family":"Gad","sequence":"first","affiliation":[{"name":"Department of Pharmacology, National Organization for Drug Control and Research  Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"5","volume":"37","author":"Henry T. 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