{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:11:05Z","timestamp":1776283865267,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The thiolation reaction was carried out in a benzene solution at 80\u00b0C and <jats:italic>p<\/jats:italic>\u2010substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The enzyme inhibition activities of the novel amides of 1,1\u2010bis\u2010(carboxymethylthio)\u20101\u2010arylethanes derivatives were investigated. These novel amides of 1,1\u2010bis\u2010(carboxymethylthio)\u20101\u2010arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). AChE inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. Many clinically established drugs are carbonic anhydrase inhibitors, and it is highly anticipated that many more will eventually find their way into the market. The novel synthesized compounds inhibited AChE and BChE with <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values in the range of 0.64\u20131.47 nM and 9.11\u201348.12 nM, respectively. On the other hand, hCA I and II were effectively inhibited by these compounds, with <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> values between 63.27\u2013132.34 and of 29.63\u2013127.31 nM, respectively.<\/jats:p>","DOI":"10.1002\/jbt.22191","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T03:48:03Z","timestamp":1531280883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Novel amides of 1,1\u2010bis\u2010(carboxymethylthio)\u20101\u2010arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Ataturk University  25240 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabiya","family":"Osmanova","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuneyt","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Bingol University  12000 Bingol Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikret","family":"Turkan","sequence":"additional","affiliation":[{"name":"Health Services Vocational School Igd\u0131r University  76000 Igd\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabira","family":"Sardarova","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagif","family":"Farzaliyev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsun","family":"Sujayev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences  1029 Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Ataturk University  25240 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Ataturk University  25240 Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"319","volume":"3","author":"Sardarova S. A.","year":"2015","journal-title":"Chem. Problems"},{"key":"e_1_2_7_3_1","first-page":"1780","volume":"4","author":"Ashvini P. P.","year":"2015","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"e_1_2_7_4_1","first-page":"296","volume":"26","author":"Nisreen H. K.","year":"2013","journal-title":"Al. Ibn Al\u2010Haitham J. Pure Appl. Sci."},{"key":"e_1_2_7_5_1","first-page":"22","volume":"5","author":"Ricci A.","year":"2007","journal-title":"Angew Chem. Int. Ed. Engl"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22000"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201700198"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21972"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180814666161128120612"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1244533"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600183"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1170014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1160077"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1149479"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1054820"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1014474"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13149"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1403-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190710103"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.04.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1156104"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1189422"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1198901"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1238367"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.03.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201700045"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21897"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.07.010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21931"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22019"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22006"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22042"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95800-X"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.763163"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.05.034"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.04.002"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101736"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201500035"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.019"},{"key":"e_1_2_7_43_1","first-page":"441","volume":"31","author":"Gocer H.","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01318a036"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501573b"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.054"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21938"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1368019"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21971"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21973"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cs00196a"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0gc00053a"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0gc00673d"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.04.006"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1014476"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2017.1360914"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21995"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2017.1373406"},{"key":"e_1_2_7_60_1","author":"T\u00fcrkan F.","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22009"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:34:10Z","timestamp":1694943250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jbt.22191"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22191","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]},"assertion":[{"value":"2018-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22191"}}