{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:38:28Z","timestamp":1770964708946,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002711","name":"Ahi Evran \u00dcniversitesi","doi-asserted-by":"publisher","award":["FEF.A4.16.003"],"award-info":[{"award-number":["FEF.A4.16.003"]}],"id":[{"id":"10.13039\/501100002711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbonic anhydrase (CA) is an important metabolic enzyme family closely related to many physiological and pathological processes. Currently, carbonic anhydrase inhibitors are the target molecules in the treatment and diagnosis of many diseases. In present study, we investigated the inhibitory effects of some indazole molecules on the CA\u2010I and CA\u2010II isoenzymes isolated from human erythrocytes. We showed that human CA\u2010I and CA\u2010II activities were reduced by of some indazoles at low concentrations. IC<jats:sub>50<\/jats:sub> values, <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> constants, and inhibition types for each indazole molecule were determined. The indazoles showed <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> constants in a range of 0.383 \u00b1 0.021 to 2.317 \u00b1 0.644\u00a0mM, 0.409 \u00b1 0.083 to 3.030 \u00b1 0.711\u00a0mM against CA\u2010I and CA\u2010II, respectively. Each indazole molecule exhibited a noncompetitive inhibition effect. Bromine\u2010 and chlorine\u2010bonded indazoles were found to be more potent inhibitory effects on carbonic anhydrase isoenzymes. In conclusion, we conclude that these results may be useful in the synthesis of carbonic anhydrase inhibitors.<\/jats:p>","DOI":"10.1002\/jbt.22194","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:06:08Z","timestamp":1531130768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["1H\u2010indazole molecules reduced the activity of human erythrocytes carbonic anhydrase I and II isoenzymes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-1756","authenticated-orcid":false,"given":"Zuhal","family":"Alim","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts K\u0131r\u015fehir Ahi Evran University  K\u0131r\u015fehir 40100 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.05.073"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.08.015"},{"key":"e_1_2_6_4_1","first-page":"1","volume":"12","author":"Supuran C. 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