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Group II received 50\u2009mg\/kg\/day chrysin for 7 days. Group III received a total dose of 73\u2009mg\/kg colistin for 7 days. Group IV received 50\u2009mg\/kg\/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin\u2009+\u2009colistin group compared with the colistin group. The highest caspase\u20103 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin\u2009+\u2009colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. 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