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The current study was intended to investigate the abnormalities in the expression of apoptosis\u2010associated proteins that lead to the progression of 7,12\u2010dimethyl benz[<jats:italic>a<\/jats:italic>]anthracene (DMBA)\u2013induced breast cancer and to expose the protective effect of taurine on it. Rats were induced with DMBA by gastric intubation to induce breast cancer. Breast cancer\u2013bearing animals were posttreated with taurine. The breast tumors induced by DMBA, analyzed in the current study, were characterized by increased protein\/DNA expression of Bcl\u20102 associated with downregulation in the expression of p53, Bax, and caspases. Taurine treatment reverted all the above changes induced by DMBA and inhibited the development of rat breast carcinoma through its ability to induce apoptosis.<\/jats:p>","DOI":"10.1002\/jbt.22204","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T08:59:02Z","timestamp":1534150742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague\u2010Dawley rats"],"prefix":"10.1002","volume":"32","author":[{"given":"Manickam Kalappan","family":"Vanitha","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Dr. ALM PGIBMS, University of Madras, Taramani Campus Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-055X","authenticated-orcid":false,"given":"Pandi","family":"Anandakumar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Health Sciences, Arsi University Asella Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanapal","family":"Sakthisekaran","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Dr. ALM PGIBMS, University of Madras, Taramani Campus Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172850"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.66"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0368-y"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.05.015"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-009-9263-3"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945012804545489"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.3831\/KPI.2015.18.027"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.2002"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-17-S1-S45"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21805"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046116"},{"key":"e_1_2_6_1_13_1","first-page":"159","volume":"62","author":"Chomczynski P.","year":"1987","journal-title":"Ann Biochem"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00048058"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v3.i3.71"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2476"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1582-1"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.990573"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802215-3.00007-0"},{"key":"e_1_2_6_1_20_1","first-page":"365","volume":"36","author":"Liang J.","year":"2005","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"5","key":"e_1_2_6_1_21_1","first-page":"677","volume":"22","author":"Zhang X.","year":"2008","journal-title":"Int J Mol Med"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:55:44Z","timestamp":1694879744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/jbt.22204"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22204","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"2018-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22204"}}