{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:11:42Z","timestamp":1783440702673,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inhalation of bacterial endotoxin induces an acute inflammation in the lower respiratory tract. The current study examined the therapeutic effects of bone marrow mesenchymal stem cells (BM\u2010MSCs) in lipopolysaccharide (LPS)\u2010induced pulmonary congestion in rats as compared with dexamethasone (Dexa) and sodium bicarbonate (NaHCO<jats:sub>3<\/jats:sub>). LPS (20\u2009\u00b5L of LPS of <jats:italic>Escherichia coli<\/jats:italic> in each nostril for two consecutive days) induced lung injury as marked by an elevation of number of inflammatory cells especially neutrophils, increased total protein levels, elevation of lipid peroxidation, and reduction of reduced glutathione in bronchoalveolar lavage along with the reduction of reduced glutathione. These deleterious effects were hampered after treatment with BM\u2010MSCs (1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009cells\/rat) once before acute lung injury (ALI) induction with LPS to an even better extent than Dexa (2\u2009mg\/kg once, ip) and NaHCO<jats:sub>3<\/jats:sub> (10\u201015\u2009mL\/day for two consecutive days). In summary, BM\u2010MSCs have the ability to suppress the endotoxin\u2010induced systemic inflammatory response and could prove to be a novel approach to therapy for ALI in rats.<\/jats:p>","DOI":"10.1002\/jbt.22217","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T03:34:14Z","timestamp":1535600054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mesenchymal stem cells therapeutic potential alleviate lipopolysaccharide\u2010induced acute lung injury in rat model"],"prefix":"10.1002","volume":"32","author":[{"given":"Maha G.","family":"Soliman","sequence":"first","affiliation":[{"name":"Department of Zoology Faculty of Science, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa A.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR) Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wedad A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR) Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha A.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Zoology Faculty of Science, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-5774","authenticated-orcid":false,"given":"Nahla A.","family":"Hassaan","sequence":"additional","affiliation":[{"name":"Department of Zoology Faculty of Science, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0883-9441(94)90033-7"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1200"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.07.007"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2134"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702791"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1391"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022361"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.1.163"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0447OC"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050813"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2009-1162"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11814-012-0042-z"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-615"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg120"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00205009"},{"issue":"4","key":"e_1_2_6_1_19_1","first-page":"393","volume":"38","author":"Lin Q.","year":"2006","journal-title":"J. Peking Univ. Healthsci."},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5575"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2004.13.436"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.08.009"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-9-33"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-950-5_7"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-79"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"e_1_2_6_1_27_1","first-page":"639","volume":"32","author":"Heiden C.","year":"1994","journal-title":"Eur. J. Clin. Chem. Biochem"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90081-5"},{"key":"e_1_2_6_1_29_1","first-page":"882","volume":"61","author":"Beutler E.","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_6_1_30_1","first-page":"414","volume":"86","author":"Montgomery H. A.","year":"1961","journal-title":"Analyst."},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80347-5"},{"issue":"3","key":"e_1_2_6_1_32_1","first-page":"139","volume":"41","author":"Vackov\u00e1 I.","year":"1992","journal-title":"Cesk. Epidemiol. Mikrobiol. Imunol."},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.2741\/A171"},{"issue":"17","key":"e_1_2_6_1_34_1","first-page":"2715","volume":"124","author":"Liang Z. X.","year":"2011","journal-title":"Chin. Med. J."},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06610.x"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2016-0036"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt68"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0006"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.12.006"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2016.1157814"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760310001607041"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22217","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:28:48Z","timestamp":1692757728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/jbt.22217"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22217","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2018-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22217"}}