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These novel N\u2010substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), \u03b1\u2010glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. <jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> values of AChE enzyme were in the range of 0.48 to 7.46\u2009nM. The hCA I and II were effectively inhibited by the compounds, with \n<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> values in the range of 502.44 to 923.11\u2009nM for hCA I and 400.32 to 801.57\u2009nM for hCA II, respectively. The antioxidant activity of the novel N\u2010substituted tetrahydropyrimidines based on phenylthiourea was investigated by using different in vitro antioxidant assays; including 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH\u00b7) radical scavenging,\u00a0Cu\n<jats:sup>2+<\/jats:sup>\u00a0and Fe\n<jats:sup>3+<\/jats:sup> reducing activities.<\/jats:p>","DOI":"10.1002\/jbt.22221","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T11:05:35Z","timestamp":1538823935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N\u2010substituted tetrahydropyrimidines based on phenylthiourea"],"prefix":"10.1002","volume":"32","author":[{"given":"Gunel","family":"Maharramova","sequence":"first","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsun","family":"Sujayev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagif","family":"Farzaliyev","sequence":"additional","affiliation":[{"name":"Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokman","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Technology Cayirli Vocational School, Erzincan Binali Y\u0131ld\u0131r\u0131m University Erzincan Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17089868"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac200476051017"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc0601377"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426500701557021"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo040281j"},{"key":"e_1_2_7_1_7_1","first-page":"3797","volume":"17","author":"Shenlin H.","year":"2005","journal-title":"Org. 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