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Male Swiss albino mice were treated with sodium valproate (SVP) with or without agmatine for 7 days. Serum and liver samples were collected for analysis. Results have revealed that agmatine exerted hepatoprotective effects against SVP\u2010associated hepatic injury. Agmatine ameliorated SVP\u2010induced elevated serum biochemical markers of hepatic damage such as serum transaminases, alkaline phosphatase, \u03b3\u2010glutamyl transferase, and lactate dehydrogenase. Histopathological examination of the liver showed improvement of hepatic lesions in case of agmatine treatment. Furthermore, agmatine attenuated oxidative stress and enhanced antioxidants in liver tissue. Agmatine inhibited the activation of nuclear factor\u2010\u03baB and ameliorated the immunoexpression of inducible nitric oxide synthetase. This was accompanied by decrease in the level of inflammatory markers as nitrite\/nitrate, tumor necrosis factor\u2010\u03b1, and interleukin\u20106. These data provide new evidence of the hepatoprotective activity of agmatine against SVP\u2010induced hepatotoxic effects.<\/jats:p>","DOI":"10.1002\/jbt.22227","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T23:57:22Z","timestamp":1538438242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Agmatine protects against sodium valproate\u2013induced hepatic injury in mice via modulation of nuclear factor\u2010\u03baB\/inducible nitric oxide synthetase pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Nishat","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Hepatology Research team College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif","family":"Aljuhani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Hepatology Research team College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind S.","family":"Al\u2010Hujaili","sequence":"additional","affiliation":[{"name":"Hepatology Research team College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar A.","family":"Al\u2010Hujaili","sequence":"additional","affiliation":[{"name":"Hepatology Research team College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Elkablawy","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Department of Pathology Faculty of Medicine, Menoufia University Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy M.","family":"Noah","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Department of Pathology Faculty of Medicine, Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Abo\u2010Haded","sequence":"additional","affiliation":[{"name":"Cardiology Unit College of Medicine, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7545-6235","authenticated-orcid":false,"given":"Dina S.","family":"El\u2010Agamy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Hepatology Research team College of Pharmacy, Taibah University Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"},{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.017855"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-017-1393-0"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2012.68.77"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.006"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(01)00217-X"},{"key":"e_1_2_5_1_7_1","first-page":"46","volume":"4","author":"Hamza A. 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