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It is also a cofactor for many proteins, enzymes, and other essential complex biochemical processes. Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation. The disruption of iron homeostasis leads to oxidative stress that causes various human diseases, but this mechanism is still unclear. The aim of this study is to provide a better in vivo and in vitro understanding of how long\u2010term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6\u2010phosphate dehydrogenase (G6PD), 6\u2010phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen. The findings of this study show that iron overload reduces the gene expression of <jats:italic>G6pd<\/jats:italic>, \n<jats:italic>6pgd<\/jats:italic>, and \n<jats:italic>Gr<\/jats:italic>, but its actual effect was on the protein level.<\/jats:p>","DOI":"10.1002\/jbt.22229","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T16:03:53Z","timestamp":1543680233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["In vitro and in vivo effects of iron on the expression and activity of glucose 6\u2010phosphate dehydrogenase, 6\u2010phosphogluconate dehydrogenase, and glutathione reductase in rat spleen"],"prefix":"10.1002","volume":"33","author":[{"given":"Nurdan","family":"Gonul Baltaci","sequence":"first","affiliation":[{"name":"Science Faculty, Department of Molecular Biology and Genetics Ataturk University Erzurum 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