{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:16:42Z","timestamp":1773663402849,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Undergraduate Student's Research Support Program","award":["URSP-109-18-3"],"award-info":[{"award-number":["URSP-109-18-3"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to compare the potential renoprotective effects of turmeric (TM) and nano turmeric (NTM) with those of desferrioxamine (DSM) against copper sulfate (CS)\u2010induced toxicity. Rats were administered a toxic dose of CS with TM, NTM, and DSM for 1 week. Next, serum\u2010urea creatinine, uric acid, interleukin (IL)\u201010, c\u2010reactive protein (CRP), and caspase\u20103 levels; renal nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), vascular cell adhesion molecule\u20101 (VCAM\u20101), kidney injury molecule (KIM)\u20101, signal transducer and activator of transcription 3 (STAT\u20103) protein expression; and nuclear factor (NF)\u2010\u03baB and B\u2010cell lymphoma \u20102 (Bcl\u20102) messenger RNA expression levels were estimated. Administration of the investigated antioxidants downregulated the marked increase in urea, creatinine, uric acid, CRP, caspase\u20103, NO, MDA, VCAM\u20101, kidney injury molecule (KIM\u20101), STAT\u20103, NF\u2010\u03baB, and DNA fragmentation, and increased Bcl\u20102, IL\u201010, GSH, and SOD levels induced by CS. The histopathological examination confirmed the effects of the antioxidants on the investigated biochemical parameters. Interestingly, NTM exhibited a superior renoprotective effect, which was comparable with that of DSM. In conclusion, NTM was shown to be a promising candidate against CS\u2010induced toxicity, and several molecular mechanisms were implicated in the CS\u2010induced renotoxicity as well as the treatment effects of NTM.<\/jats:p>","DOI":"10.1002\/jbt.22243","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:35:30Z","timestamp":1542324930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule\u20101, kidney injury molecule\u20101, and signal transducer and activator of transcription 3 protein expressions"],"prefix":"10.1002","volume":"33","author":[{"given":"Bshayer","family":"Alharbi","sequence":"first","affiliation":[{"name":"Student at Faculty of Pharmacy, King Saud University Riyadh Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Fadda","sequence":"additional","affiliation":[{"name":"Pharmacology Department Faculty of Pharmacy, King Saud University Riyadh Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-7585","authenticated-orcid":false,"given":"Hanaa M","family":"Ali","sequence":"additional","affiliation":[{"name":"First Common Year Deanship, King Saud University Riyadh Kingdom of Saudi Arabia"},{"name":"Department of Genetics and Cytology National Research Centre Dokki Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(01)00078-5"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.1.L172"},{"key":"e_1_2_8_1_4_1","first-page":"247","volume":"8","author":"Pohl H. 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