{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:33:42Z","timestamp":1771950822747,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770279"],"award-info":[{"award-number":["81770279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500649"],"award-info":[{"award-number":["31500649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M610342"],"award-info":[{"award-number":["2017M610342"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sirtuin3 (SIRT3) plays an important role in maintaining normal mitochondrial function and alleviating oxidative stress. After carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) administration, the expression of SIRT3 decreased in the liver of mice, which indicated that the SIRT3 might play a crucial role during chemical\u2010induced acute hepatic injury. To verify the hypothesis, CCl\n<jats:sub>4<\/jats:sub> was given to induce acute hepatic injury in SIRT3 knockout (KO) mice and wild\u2010type (WT) mice. CCl\n<jats:sub>4<\/jats:sub>\u2010induced liver injury was more severe in SIRT3 KO mice compared with the WT mice. In addition, the oxidative stress induced by CCl\n<jats:sub>4<\/jats:sub> was enhanced in the SIRT3 KO mice. Furthermore, the increased expression of dynamin\u2010related protein 1 was also aggravated in SIRT3 KO mice after CCl\n<jats:sub>4<\/jats:sub> administration. In conclusion, our study demonstrated that SIRT3 deficiency exacerbated CCl\n<jats:sub>4<\/jats:sub>\u2010induced impairment of the liver in mice, and the mechanism might be related to enhanced oxidative stress.<\/jats:p>","DOI":"10.1002\/jbt.22249","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T16:14:50Z","timestamp":1540743290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sirtuin3 deficiency exacerbates carbon tetrachloride\u2212induced hepatic injury in mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Xinshuai","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-405X","authenticated-orcid":false,"given":"Yuqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy, Nantong University, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26209"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2017.12.019"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.01.005"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.06.010"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.04.012"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2016-0316"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7290"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.01.002"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100075"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.015"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.002"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01483-13"},{"key":"e_1_2_7_1_14_1","first-page":"2758","volume":"119","author":"Sundaresan N. R.","year":"2009","journal-title":"J. Clin. Invest."},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118909"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077271"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.564"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.692244"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.047"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21714"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12367"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.03.013"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.01.009"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.10.011"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.08.006"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.144"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201704561"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0347-y"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150961"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.006"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6331"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13861"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300851"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011707"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010144"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-016-1295-5"},{"key":"e_1_2_7_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7656"},{"key":"e_1_2_7_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.022"},{"key":"e_1_2_7_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.011"},{"key":"e_1_2_7_1_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16133"},{"key":"e_1_2_7_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.03.027"},{"key":"e_1_2_7_1_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9627-y"},{"key":"e_1_2_7_1_43_1","author":"Zeng X.","journal-title":"Antioxid. Redox. Signal."}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:44:57Z","timestamp":1694699097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,28]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/jbt.22249"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22249","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,28]]},"assertion":[{"value":"2018-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22249"}}