{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:34:59Z","timestamp":1785792899537,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study pointed to estimate the possible protective impacts of candesartan and\/or epigallocatechin\u20103\u2010gallate (EGCG) against gentamicin\u2010induced nephrotoxicity. The current work revealed that gentamicin significantly elevated relative kidney weight and the serum level of creatinine and urea. Also, renal level of malondialdehyde was significantly increased with a concurrent decrease in renal glutathione\u2010S\u2010transferase and superoxide dismutase activities. Moreover, renal levels of nuclear factor\u2010kappa B (NF\u2010\u03baB) and p38 mitogen\u2010activated protein kinase (p38\u2010MAPK) were increased together with the elevation of tumor necrosis factor\u2010alpha and interleukin\u20101 beta levels after gentamicin treatment. In addition, caspase\u20103 expression was elevated, and histological examination revealed extreme alterations enlightening inflammation, degeneration, and necrosis. Pretreatments with candesartan and\/or EGCG attenuated gentamicin\u2010induced nephrotoxicity. Importantly, the altered expression of p38\u2010MAPK and NF\u2010\u03baB may play a significant role in the protective mechanisms exerted by candesartan and EGCG. Coadministration of candesartan and EGCG exhibited more profound response compared with the monotherapy.<\/jats:p>","DOI":"10.1002\/jbt.22254","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T14:09:15Z","timestamp":1540735755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Candesartan and epigallocatechin\u20103\u2010gallate ameliorate gentamicin\u2010induced renal damage in rats through p38\u2010MAPK and NF\u2010\u03baB pathways"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-6210","authenticated-orcid":false,"given":"Hebatalla I.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/500137"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.5812\/nephropathol.7512"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy09t1.094234"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325457"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020149"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.5812\/nephropathol.7533"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr195"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00557-2"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220902835863"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164528"},{"key":"e_1_2_6_1_12_1","first-page":"29","volume":"2","author":"Nasri H.","year":"2012","journal-title":"Inj. Prev."},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.05.007"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215577582"},{"key":"e_1_2_6_1_15_1","first-page":"S91","volume":"11","author":"Sever P.","year":"1997","journal-title":"J. Hum. Hypertens."},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0239-7"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.053322"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4432"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.9.451"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.07.093"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.09.010"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b03301"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v028a26"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481643"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.05.005"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.569"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.08.020"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21833"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.2.156"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(72)90432-9"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(85)90216-7"},{"key":"e_1_2_6_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_6_1_35_1","volume-title":"Theory and Practice of Histological Techniques","author":"Bancroft J.","year":"1996"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.8.1175"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.79"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.06.101"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.10.021"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.337"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/390613"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1369"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.533669"},{"key":"e_1_2_6_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-010-0068-y"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.698283"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000436975"},{"key":"e_1_2_6_1_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/841343"},{"issue":"6","key":"e_1_2_6_1_48_1","first-page":"1629","volume":"18","author":"Kabel A. M.","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_6_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1030-0"},{"key":"e_1_2_6_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05005-9"},{"key":"e_1_2_6_1_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489210"},{"key":"e_1_2_6_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.02.014"},{"key":"e_1_2_6_1_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020166"},{"key":"e_1_2_6_1_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000048715.12315.FD"},{"key":"e_1_2_6_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63138-0"},{"key":"e_1_2_6_1_56_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006000600016"},{"key":"e_1_2_6_1_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01412-06"},{"key":"e_1_2_6_1_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1517"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T06:21:57Z","timestamp":1694672517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,28]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/jbt.22254"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22254","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,28]]},"assertion":[{"value":"2018-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22254"}}