{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:56:06Z","timestamp":1789934166082,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81071005"],"award-info":[{"award-number":["81071005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As a gasotransmitter, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) plays a crucial role in regulating the signaling pathway mediated by oxidative stress. The purpose of this study was to investigate the protective effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S on uranium\u2010induced rat hepatocyte cytotoxicity. Primary hepatocytes were isolated and cultured from\n                    <jats:italic>Sprague Dawley<\/jats:italic>\n                    rat liver tissues. After pretreating with sodium hydrosulfide (an H\n                    <jats:sub>2<\/jats:sub>\n                    S donor) for 1\u2009hour (or GKT\u2010136901 for 30\u2009minutes), hepatocytes were treated by uranyl acetate for 24\u2009hours. Cell viability, reactive oxygen species (ROS), malondialdehyde (MDA), NADPH oxidase 4 (Nox4), and p38 mitogen\u2010activated protein kinase (p38 MAPK) phosphorylation were respectively determined. The effects of direct inhibition of Nox4 expression by GKT\u2010136901 (a Nox4 inhibitor) on ROS and phospho\u2010p38 MAPK levels were examined in uranium\u2010treated hepatocytes. The results implicate that H\n                    <jats:sub>2<\/jats:sub>\n                    S can afford protection of rat hepatocytes against uranium\u2010induced adverse effects through attenuating oxidative stress via prohibiting Nox4\/ROS\/p38 MAPK signaling.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22255","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T10:15:19Z","timestamp":1540721719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hydrogen sulfide alleviates uranium\u2010induced rat hepatocyte cytotoxicity via inhibiting Nox4\/ROS\/p38 MAPK pathway"],"prefix":"10.1002","volume":"33","author":[{"given":"Juan","family":"Yi","sequence":"first","affiliation":[{"name":"Department and Institute of Biology, School of Pharmaceutical and Biological Science, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department and Institute of Biology, School of Pharmaceutical and Biological Science, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-6484","authenticated-orcid":false,"given":"Jifang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department and Institute of Biology, School of Pharmaceutical and Biological Science, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department and Institute of Biology, School of Pharmaceutical and Biological Science, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-005-0027-3"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0028"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-198107000-00012"},{"key":"e_1_2_6_1_5_1","first-page":"789","volume":"57","author":"Belosludtsev K. 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