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To fulfill this aim, gastric acid secretion stimulated with histamine (5\u2009mg\/kg, subcutaneous [SC]), 2\u2010deoxy\u2010\n<jats:sc>d<\/jats:sc>\u2010glucose (D\u2010G) (200\u2009mg\/kg, intravenous) or \u2010carbachol (4\u2009\u03bcg\/kg, SC) in the 4\u2010hour pylorus\u2010ligated rats. The CB1R agonist (\n<jats:italic>N<\/jats:italic>\u2010arachidonoyl dopamine, 1\u2009mg\/kg, SC) inhibited gastric acid secretion stimulated by D\u2010G and carbachol but not in histamine, reduced pepsin content, and increased mucin secretion. Furthermore, it decreased malondialdehyde (MDA) and nitric oxide (NO) contents with an increase in glutathione (GSH) and paraoxonase 1 (PON\u20101). Meanwhile, CB2R antagonist (AM630, 1\u2009mg\/kg, SC) inhibited gastric acid secretion stimulated by D\u2010G and reduced MDA and NO contents with an increase in GSH and PON\u20101. Meanwhile, CB1R antagonist rimonabant or CB2R agonist GW 405833 had no effect on stimulated gastric acid secretion. Therefore, both CB1R agonist and CB2R antagonist may exert antisecretory and antioxidant potential in the stomach.<\/jats:p>","DOI":"10.1002\/jbt.22256","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T07:50:06Z","timestamp":1541058606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Modulation of gastric acid secretion by cannabinoids in rats"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-5449","authenticated-orcid":false,"given":"Rania A. 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