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These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with \n<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> values in the range of 447.28 to 1004.65\u2009nM for hCA I, 309.44 to 935.93\u2009nM for hCA II, and 0.28 to 4.01\u2009nM for AChE, respectively. Novel substituted thiophene derivatives can be good candidate drugs for the treatment of some diseases like neurological disorders, epilepsy, glaucoma, gastric and duodenal ulcers, mountain sickness, or osteoporosis as carbonic anhydrase isozymes inhibitors, and for the treatment of Alzheimer\u2019s and Parkinson\u2019s diseases as acetylcholinesterase inhibitors.<\/jats:p>","DOI":"10.1002\/jbt.22261","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T13:58:55Z","timestamp":1544450335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-9489","authenticated-orcid":false,"given":"Adnan","family":"Cetin","sequence":"first","affiliation":[{"name":"Department of Science Faculty of Education, Mu\u015f Alparslan University Mu\u015f Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-3157","authenticated-orcid":false,"given":"Fikret","family":"T\u00fcrkan","sequence":"additional","affiliation":[{"name":"Health Services Vocational School, Igd\u0131r University Igd\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.033"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.05.004"},{"key":"e_1_2_7_1_4_1","first-page":"317","volume":"8","author":"Rai U. 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