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In this study, we investigated the effect of Flu on SANFH and the role played by the STAT1\/caspase\u20103 signaling pathway. Sprague\u2010Dawley rats were divided into control, SANFH, and Flu\u2010treated SANFH groups. Femoral head tissues were collected for hematoxylin\u2010eosin (H&amp;E) staining and Western blot analysis. The latter was used to measure the levels of stat1, phospho\u2010stat1, caspase\u20103, cleaved caspase\u20103, caspase\u20109, cleaved caspase\u20109, Bax, cytochrome C, Bak, B\u2010cell lymphoma\u2010extra large, and\u00a0B\u2010cell lymphoma\u20102 protein expression. The results showed that Flu regulates protein expression in dexamethasone (Dex)\u2010induced SANFH. H&amp;E staining showed a decrease in the ratio of empty lacunae induced by Dex. Taken together, our study demonstrated the involvement of the STAT1\/caspase\u20103 signaling pathway in SANFH and the potential of Flu as a therapeutic agent for patients with SANFH.<\/jats:p>","DOI":"10.1002\/jbt.22265","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T09:43:17Z","timestamp":1543657397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Downregulating STAT1\/caspase\u20103 signaling with fludarabine to alleviate progression in a rat model of steroid\u2010induced avascular necrosis of the femoral head"],"prefix":"10.1002","volume":"33","author":[{"given":"Jian","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihui","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-6474","authenticated-orcid":false,"given":"Xiaoyun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou China"},{"name":"Key Laboratory of Orthopaedics of Zhejiang Province Wenzhou China"},{"name":"The Second School of Medicine, Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12]]},"reference":[{"issue":"2","key":"e_1_2_7_1_2_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3760\/cma.j.issn.0366-6999.20120663","volume":"126","author":"Wang X. 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