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In this evaluation, \n<jats:bold>6f<\/jats:bold> was found to be the most active compound showing the same effect as the positive control against \n<jats:italic>Bacillus subtilis<\/jats:italic> and \n<jats:italic>Streptococcus pyogenes<\/jats:italic> in terms of antimicrobial activity. Biofilm structures formed by microorganisms were damaged by compounds at the minimum inhibitory concentration value between 0.5% and 97%.1,3\u2010bis\u2010chalcones (\n<jats:bold>3a\u2010i, 6a\u2010i<\/jats:bold> and \n<jats:bold>8<\/jats:bold>) showed good inhibitory action against human (h) carbonic anhydrase (CA) isoforms I and II. hCA I and II were effectively inhibited by these compounds, with \n<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> values in the range of 94.33\u2009\u00b1\u200913.26 to 787.38\u2009\u00b1\u200982.64\u2009nM for hCA I, and of 100.37\u2009\u00b1\u200911.41 to 801.76\u2009\u00b1\u200991.11\u2009nM for hCA II, respectively. In contrast, acetazolamide clinically used as CA inhibitor showed \n<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub> value of 1054.38\u2009\u00b1\u2009207.33\u2009nM against hCA I, and 983.78\u2009\u00b1\u2009251.08\u2009nM against hCA II, respectively.<\/jats:p>","DOI":"10.1002\/jbt.22281","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:42:48Z","timestamp":1546296168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Evaluation of antimicrobial, antibiofilm and carbonic anhydrase inhibition profiles of 1,3\u2010bis\u2010chalcone derivatives"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-0994","authenticated-orcid":false,"given":"U\u011fur","family":"Tutar","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences, Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-2912","authenticated-orcid":false,"given":"\u00dcmit M.","family":"Ko\u00e7yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Vocational School of Health Services, Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-7400","authenticated-orcid":false,"given":"Hayreddin","family":"Gezegen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences, Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-015-0527-5"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v15i5.20"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.07.012"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21938"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21972"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2017.1373406"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21971"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201700198"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21897"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180814666161128120612"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1238367"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2860(98)00859-X"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900027"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00828.x"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10010221"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.02.038"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04904.x"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/poc.3071"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401893j"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.07.004"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201100077"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.07.080"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2013.845902"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.409"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10593-010-0455-8"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.02.007"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1603-112"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-016-2697-2"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1604-84"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111872"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.5b00132"},{"key":"e_1_2_6_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201600157"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1jm11898f"},{"key":"e_1_2_6_1_36_1","first-page":"368","volume":"43","author":"Joshi J.","year":"1966","journal-title":"J. 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