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In this study, we investigated the cardioprotective effect of HES in isoproterenol (ISO)\u2010induced CH through PPAR\u2010\u03b3 agonistic activity. For this, male albino Wistar rats were divided into six groups (n\u2009=\u20096), that is, normal, ISO\u2010control, HES treatment group (200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; p.o.), HES<jats:italic>per se<\/jats:italic>(200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; p.o.), enalapril treatment group (30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; p.o.), and combination group (HES 200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; p.o.+enalapril 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; p.o.). ISO (3\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>; s.c.) was administered to all groups except normal and<jats:italic>per se<\/jats:italic>to induce CH. HES or enalapril treatment of 28 days significantly attenuated pathological changes, improved cardiac hemodynamics, suppressed oxidative stress, and apoptosis along with an increased PPAR\u2010\u03b3 expression. The combination of enalapril with HES exhibited an effect similar to that of HES or enalapril alone on all the aforementioned parameters. Therefore, HES may be further evaluated as a promising molecule for the alleviation of CH.<\/jats:p>","DOI":"10.1002\/jbt.22283","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:00:15Z","timestamp":1547020815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Hesperidin regresses cardiac hypertrophy by virtue of PPAR\u2010\u03b3 agonistic, anti\u2010inflammatory, antiapoptotic, and antioxidant properties"],"prefix":"10.1002","volume":"33","author":[{"given":"Poorva","family":"Bhargava","sequence":"first","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Irfan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagriti","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-0775","authenticated-orcid":false,"given":"Dharamvir Singh","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Laboratory, All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.11.009"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06254"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02313"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200202010-00001"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.02.004"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.90879"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9174190"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000179226.34112.6d"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105225"},{"key":"e_1_2_8_1_11_1","first-page":"803","volume":"14","author":"McMurray J. 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