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Male rats were randomly allocated into three groups: a control group, CCl\n<jats:sub>4<\/jats:sub> fibrotic group, and CCl\n<jats:sub>4<\/jats:sub>+rivaroxaban (5\u2009mg\/kg) group. Liver fibrosis was induced by subcutaneous injection of CCl\n<jats:sub>4<\/jats:sub> twice a week for 6 weeks. Rivaroxaban significantly restored the biochemical parameter including inflammatory and fibrosis markers with histopathological evidence using routine and Masson trichrome staining. It reduced also the expression of tissue factor, fibrin, transforming growth factor and \u03b1\u2010smooth muscle actin in the liver tissues. This concludes that rivaroxaban attenuates liver injury caused by CCl\n<jats:sub>4<\/jats:sub>, at least in part by inhibiting coagulation and proinflammatory activation. In conclusion, rivaroxaban may be used for the management of liver fibrosis.<\/jats:p>","DOI":"10.1002\/jbt.22287","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T11:14:43Z","timestamp":1549365283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition of activated factor X; a new pathway in ameliorating carbon tetrachloride\u2013induced liver fibrosis in rats"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-5968","authenticated-orcid":false,"given":"Nesreen Ishak","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Nahda University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basim Anwar Shehata","family":"Messiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Ahmed","family":"Abo\u2010Saif","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Nahda University Beni\u2010Suef Egypt"},{"name":"Department of Pharmacology Faculty of Medicine, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Sadek","family":"Abdel\u2010Bakky","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Nahda University Beni\u2010Suef Egypt"},{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.03.011"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.12.013"},{"issue":"4","key":"e_1_2_7_1_4_1","first-page":"625","volume":"112","author":"Esmon C. 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