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Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), and high\u2010density lipoprotein (HDL) levels, as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme activities, were measured 7 weeks after the administration of STZ and atorvastatin. Thiobarbituric acid reactive substances (TBARS), non\u2010protein associated sulfhydryl (NP\u2010SH), total sulfhydryl (T\u2010SH), and nitric oxide (NO) levels were measured to evaluate oxidative stress. Atorvastatin was found to inhibit ALT and AST activities and to reduce FBG levels in rats with STZ\u2010induced diabetes. Moreover, atorvastatin treatment significantly reduced lipid peroxidation in kidney, heart, and eye tissues (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, for all), and resulted in a significant increase in NP\u2010SH levels in brain tissues (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Total NO and nitrate levels increased significantly after atorvastatin treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Our results revealed that atorvastatin has a protective effect against STZ\u2010induced oxidative damage by reducing TBARS levels and increasing NP\u2010SH levels, has a hepatoprotective effect by decreasing ALT and AST activities. It also shows the antihyperglycemic activity by lowering FBG levels.<\/jats:p>","DOI":"10.1002\/jbt.22295","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T16:51:43Z","timestamp":1547830303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective effect of atorvastatin on oxidative stress in streptozotocin\u2010induced diabetic rats independently their lipid\u2010lowering effects"],"prefix":"10.1002","volume":"33","author":[{"given":"G\u00f6knur","family":"Aktay","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy, \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eule \u00d6ner","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy, \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Uyumlu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy, \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-490X","authenticated-orcid":false,"given":"Song\u00fcl","family":"\u00dcn\u00fcvar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology Faculty of Pharmacy, \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine, F\u0131rat University Elaz\u0131\u011f Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"e_1_2_7_1_2_1","unstructured":"World Health Organization (WHO) Global Report on Diabetes Geneva Switzerland 2016.http:\/\/apps.who.int\/iris\/bitstream\/10665\/204871\/1\/9789241565257_eng.pdf?ua=1"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.5897\/JPAP2013.0001"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.05.009"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/cd16-0067"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0584-7"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021993"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00195-X"},{"issue":"2","key":"e_1_2_7_1_9_1","first-page":"e43319","volume":"15","author":"Meor Anuar Shuhaili M. 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