{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078650,"version":"build-2736575974"},"reference-count":87,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human carbonic anhydrase I and II isoenzymes (hCA I and II) and acetylcholinesterase (AChE) are important metabolic enzymes that are closely associated with various physiological and pathological processes. In this study, we investigated the inhibition effects of some sulfonamides on hCA I, hCA II, and AChE enzymes. Both hCA isoenzymes were purified by Sepharose\u20104B\u2010L\u2010Tyrosine\u20105\u2010amino\u20102\u2010methylbenzenesulfonamide affinity column chromatography with 1393.44 and 1223.09\u2010folds, respectively. Also, some inhibition parameters including IC\n                    <jats:sub>50<\/jats:sub>\n                    and\n                    <jats:italic>\n                      K\n                      <jats:sub>i<\/jats:sub>\n                    <\/jats:italic>\n                    values were determined. Sulfonamide compounds showed IC\n                    <jats:sub>50<\/jats:sub>\n                    values of in the range of 55.14 to 562.62\u2009nM against hCA I, 55.99 to 261.96\u2009nM against hCA II, and 98.65 to 283.31\u2009nM against AChE.\n                    <jats:italic>\n                      K\n                      <jats:sub>i<\/jats:sub>\n                    <\/jats:italic>\n                    values were in the range of 23.40\u2009\u00b1\u20099.10 to 365.35\u2009\u00b1\u200924.42\u2009nM against hCA I, 45.87\u2009\u00b1\u20095.04 to 230.08\u2009\u00b1\u200992.23\u2009nM against hCA II, and 16.00\u2009\u00b1\u200945.53 to 157.00\u2009\u00b1\u20094.02\u2009nM against AChE. As a result, sulfonamides had potent inhibition effects on these enzymes. Therefore, we believe that these results may contribute to the development of new drugs particularly in the treatment of some disorders.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22300","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T18:49:19Z","timestamp":1551293359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-4623","authenticated-orcid":false,"given":"Zeynep","family":"K\u00f6ksal","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-1194","authenticated-orcid":false,"given":"Zuhal","family":"Al\u0131m","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science and Arts, K\u0131r\u015fehir Ahi Evran University K\u0131rsehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-2760","authenticated-orcid":false,"given":"Song\u00fcl","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-0442","authenticated-orcid":false,"given":"Hasan","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501573b"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.019"},{"key":"e_1_2_6_1_5_1","first-page":"3057384","author":"Huyut Z.","year":"2016","journal-title":"Biomed Res. 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