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Curcuminoids exhibit a wide range of pharmacological activities that are beneficial for health, including hepatoprotective effects, but its clinical significance is limited due to poor oral bioavailability. In the present study, a novel formulation of curcumin as curcumin\u2010galactomannosides (CGM) with enhanced oral bioavailability alleviated alcohol\u2010induced liver damage in wistar rats with an increased potency compared to the unformulated natural curcuminoids (CM). Ethanol administration significantly elevated liver toxicity markers, lipid peroxidation and inflammatory markers with a simultaneous reduction in antioxidant defenses. Supplementation of CGM reversed all of the pathological effects of alcohol administration, almost close to the normal level, when compared with CM. Histopathology of liver tissue also confirmed the better protective effect of CGM, indicating the enhancement in antioxidant and anti\u2010inflammatory effects as a function of bioavailability.<\/jats:p>","DOI":"10.1002\/jbt.22315","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T05:28:11Z","timestamp":1550813291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Curcumin\u2010galactomannosides mitigate alcohol\u2010induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4\/MMP events compared to curcumin"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-1633","authenticated-orcid":false,"given":"Ratheesh","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Biochemistry St. Thomas College  Kottayam Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenia","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Biochemistry St. Thomas College  Kottayam Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandya","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Physical Chemistry Indian Institute of Science  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"S","sequence":"additional","affiliation":[{"name":"Department of Biochemistry St. Thomas College  Kottayam Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheethal","family":"S","sequence":"additional","affiliation":[{"name":"Department of Biochemistry St. Thomas College  Kottayam Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"John","sequence":"additional","affiliation":[{"name":"Department of Biochemistry St. Thomas College  Kottayam Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnakumar","family":"I M","sequence":"additional","affiliation":[{"name":"R&amp;D Centre, Akay Flavours &amp; Aromatics Pvt Ltd  Cochin Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"issue":"2","key":"e_1_2_7_1_2_1","first-page":"85","volume":"1","author":"Partha P.","year":"2016","journal-title":"Eur. 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