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However, the underlying mechanism of how transgenerational effects occur as part of environmental chemical exposure are not well understood. We investigated the potential molecular changes associated with dibutyl phthalate exposure that induced transgenerational effects, using a rat model. Through the analysis of the Gene Expression Omnibus database, we found some similar studies of environmental exposure induced transgenerational effects. Then, we analyzed one of the studies and our results to identify the adenomatous polyposis coli (APC) gene. This gene participated the most of the pathways and was upregulated in both studies. We used the miRWALK data set to predict the microRNAs which targeted the APC gene. We confirmed the miR\u201030 family were significantly downregulated in F3 testis tissues and targeted the APC gene. In conclusion, the miR\u201030 family\/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical.<\/jats:p>","DOI":"10.1002\/jbt.22331","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T17:01:06Z","timestamp":1554138066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adenomatous polyposis coli as a predictor of environmental chemical\u2010induced transgenerational effects related to male infertility"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-2028","authenticated-orcid":false,"given":"Beilei","family":"Yuan","sequence":"first","affiliation":[{"name":"College of Safety Science and Engineering Nanjing Tech University Nanjing Jiangsu China"},{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huazhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juncheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Safety Science and Engineering Nanjing Tech University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-13-43"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2174\/0929867324666171009121001","volume":"25","author":"Chianese R.","year":"2018","journal-title":"Curr. 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