{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:22:17Z","timestamp":1778584937623,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Streptococcus pneumoniae<\/jats:italic> causes many human diseases including bacterial meningitis. Previous study proposed that pneumolysin (PLY), a cytotoxin from pneumococcus, is related to the infection across blood\u2010brain barrier (BBB). However, the mechanism of how PLY break through BBB remains elusive. The present study showed that PLY can increase the permeability of BBB both in vitro and in vivo in our experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Further we found out that PLY leads to the high expression of CERB\u2010binding protein (CBP) which can lead to releasing of tumor necrosis factor \u03b1 then enhance apoptosis of cells which is a significant factor leading to permeabilization of BBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings demonstrate that CBP plays an important role in the pneumococcus infection in the brain and could be a potential therapeutic target against pneumococcal meningitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbt.22333","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T05:50:22Z","timestamp":1555134622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Upregulation of CBP by PLY can cause permeability of blood\u2010brain barrier to increase meningitis"],"prefix":"10.1002","volume":"33","author":[{"given":"Jia\u2010Quan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Encephalopathy Yantai Traditional Chinese Medicine Hospital Yantai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan\u2010Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy Oriental Hospital of Beijing University of Chinese Medicine Beijing People's Republic of 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