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In the present study, we explored the effect of topically and orally administered losartan (an angiotensin receptor blocker) on streptozotocin\u2010induced diabetic cataract in albino rats. Topical treatment with losartan modulated neither the blood glucose level nor the polyol content but oral treatment with losartan decreased both. Topical and oral treatment with losartan significantly increased the antioxidants (glutathione, glutathione peroxidase, superoxide dismutase, and catalase), decreased the lipid peroxidant malondialdehyde, and restored soluble protein, and insoluble protein and various ions (Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>, and Ca<jats:sup>2+<\/jats:sup>) in the lens; however, topical treatment had a better effect than oral treatment. These findings demonstrate that topical administration of losartan significantly reduces the risk of cataract formation without affecting either the blood glucose level or polyol contents.<\/jats:p>","DOI":"10.1002\/jbt.22342","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T16:34:21Z","timestamp":1554741261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Losartan delays the progression of streptozotocin\u2010induced diabetic cataracts in albino rats"],"prefix":"10.1002","volume":"33","author":[{"given":"Jaya","family":"Shree","sequence":"first","affiliation":[{"name":"Department of Pharmacology, SLT Institute of Pharmaceutical Sciences Guru Ghasidas Vishwavidyalaya  Bilaspur Chhattisgarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SLT Institute of Pharmaceutical Sciences Guru Ghasidas Vishwavidyalaya  Bilaspur Chhattisgarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-8337","authenticated-orcid":false,"given":"Surendra H","family":"Bodakhe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SLT Institute of Pharmaceutical Sciences Guru Ghasidas Vishwavidyalaya  Bilaspur Chhattisgarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300539"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6373"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71170-5"},{"issue":"1","key":"e_1_2_7_1_5_1","first-page":"52","volume":"3","author":"Javadi M. \u2010A.","year":"2008","journal-title":"J. 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