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For this purpose, we used monodispersed MPA\u2010COOH\u2010CdTe QDs with different diameters (emission length at 560 and 625\u2009nm, named as QD\u2010560 and QD\u2010625). Such QDs tended to accumulate in cells and cause significant toxicity. Using specific inhibitors of ABC transporters, the cellular accumulation and toxicity of QDs in SK\u2010BR\u20103 cells were significantly affected. Moreover, treatment of QDs caused concentration\u2010 and time\u2010dependent induction of ABC transporters. Furthermore, the induction effects of smaller QDs were found to be greater than larger ones at equivalent concentrations, suggesting a size\u2010dependent recognition of substrates by ABC transporters. Overall, these results provided important support for the modulation of QDs toxicity by ABC transporters.<\/jats:p>","DOI":"10.1002\/jbt.22343","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T15:39:52Z","timestamp":1555774792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Involvement of ABC transporters in the efflux and toxicity of MPA\u2010COOH\u2010CdTe quantum dots in human breast cancer SK\u2010BR\u20103 cells"],"prefix":"10.1002","volume":"33","author":[{"given":"Gui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery The Third Affiliated Hospital of Soochow University  Changzhou Jiangsu PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery The Third Affiliated Hospital of Soochow University  Changzhou Jiangsu PR 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