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Today, it is suggested that cisplatin\u2010associated toxicities are mainly induced by free radicals production, which will result in oxidative organ injury. The evidence is growing over the protective effects of antioxidants on cisplatin\u2010induced adverse reactions especially nephrotoxicity. The possible protective effects of vitamin E and its derivative in cisplatin\u2010induced nephrotoxicity and ototoxicity are reviewed here at the light of pertinent results from basic and clinical research. Administration of vitamin E alone or in combination with other antioxidant agents could cause amelioration in oxidative stress biomarkers such as decreasing the level of malondialdehyde, reducing serum urea and creatinine, and also enhancing the activities of renal antioxidant enzymes including renal catalase, glutathione\u2010S\u2010transferase, and superoxide dismutase. Although the data from most of the studies are in favors of protective effects of vitamin E against cisplatin\u2010induced toxicity, more clinical trials are needed to clarify the clinical importance of vitamin E administration as an antioxidant during cisplatin therapy in cancer condition.<\/jats:p>","DOI":"10.1002\/jbt.22349","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T08:34:02Z","timestamp":1558514042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Has vitamin E any shreds of evidence in cisplatin\u2010induced toxicity"],"prefix":"10.1002","volume":"33","author":[{"given":"Bahareh","family":"Hakiminia","sequence":"first","affiliation":[{"name":"Clinical Pharmacy and Pharmacy Practice Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Health Science Center School of Pharmacy  TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-6172","authenticated-orcid":false,"given":"Azadeh","family":"Moghaddas","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Pharmacy Practice Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2112490"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503305200"},{"issue":"4","key":"e_1_2_5_1_5_1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1681\/ASN.V134858","volume":"13","author":"Park M. 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