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In this study, we examined the expression and functional roles of human endogenous \u03b1 defensins in diabetic foot ulcer. The expression levels of human \u03b1 defensins HNP1, HNP3, and HNP4 were significantly higher in the wound center than the edge of diabetic foot ulcers. And the inflammatory cytokine interleukin IL\u20108 (IL\u20108) was also highly expressed in wound exudates. In human foreskin fibroblasts, these human \u03b1 defensins were found only slightly to affect IL\u20108 expression directly. hemoglobin A1C (HbA1c) is the main clinical indicator of diabetic foot disease. Advanced glycation end products of bovine serum albumin (AGE\u2010BSA), as HbA1c analogue, was found to promote IL\u20108 expression. Human \u03b1 defensins, in the presence of AGE\u2010BSA, further significantly promoted IL\u20108 expression. These findings showed that human \u03b1 defensins aggravated the inflammatory response in diabetic foot ulcers patients, providing new insights in to the poor healing of diabetic foot ulcers.<\/jats:p>","DOI":"10.1002\/jbt.22351","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T16:14:14Z","timestamp":1559578454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Human \u03b1 defensins promote the expression of the inflammatory cytokine interleukin\u20108 under high\u2010glucose conditions: Novel insights into the poor healing of diabetic foot ulcers"],"prefix":"10.1002","volume":"33","author":[{"given":"Lanxia","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Neurology Renmin Hospital of Wuhan University  Wuhan Hubei 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