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B2BrBC and C66 treatments did not prevent the monocrotaline\u2010induced right ventricular hypertrophy but attenuated the changes in antioxidant enzyme activities and reduced inflammation. The level of thiol\u2010based nonenzymatic antioxidants did not change in the function of monocrotaline or curcumin analogs treatment. However, due to its stronger antioxidant properties, only B2BrBC treatment was effective in the reduction of monocrotaline\u2010associated lipid peroxidation. The obtained results suggest that increasing the levels of antioxidant enzymes may not be sufficient to reduce oxidative stress and chronic inflammation optimally and our current study supports the potential of compounds with more than one beneficial biological activity as a promising treatment against the progression of cardiac hypertrophy.<\/jats:p>","DOI":"10.1002\/jbt.22353","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T16:37:16Z","timestamp":1560184636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antioxidant and anti\u2010inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline\u2010induced right ventricular hypertrophy"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-7359","authenticated-orcid":false,"given":"Nikola","family":"Hadzi\u2010Petrushev","sequence":"first","affiliation":[{"name":"Faculty of Natural Sciences and Mathematics, Institute of Biology \u201cSs. 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