{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078761,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Planning Project of Yuzhong district of Chongqing","award":["20170410"],"award-info":[{"award-number":["20170410"]}]},{"name":"Leadership Project in Karamay City, XinJiang"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    \u03b2\u2010Hydroxybutyrate (BHB), one of ketone body, has been traditionally regarded as an alternative carrier of energy, but recent studies found that BHB plays versatile roles in inflammation. It has been previously reported that the level BHB declined in mice with lipopolysaccharide (LPS)\/\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactosamine (\n                    <jats:sc>d<\/jats:sc>\n                    \u2010Gal)\u2010induced liver damage, but the pathological significance remains unclear. In the present study, the pathophysiological roles of BHB in LPS\/\n                    <jats:sc>d<\/jats:sc>\n                    \u2010Gal\u2010induced hepatic damage has been investigated. The results indicated pretreatment with BHB further enhanced LPS\/\n                    <jats:sc>d<\/jats:sc>\n                    \u2010Gal\u2010induced elevation of aspartate aminotransferase and alanine aminotransferase, exacerbated the histological abnormalities and increased the mortality. Pretreatment with BHB upregulated the level of tumor necrosis factor \u03b1 and interleukin\u20106 in plasma, promoted the activities of caspase\u20103, caspase\u20108, and caspase\u20109 and increased the count of terminal deoxynucleotidyl transferase dUTP nick end labeling\u2010positive cells. In addition, post\u2010insult supplement with BHB also potentiated LPS\/\n                    <jats:sc>d<\/jats:sc>\n                    \u2010Gal\u2010induced apoptotic liver damage. Therefore, BHB might be a detrimental factor in LPS\/\n                    <jats:sc>d<\/jats:sc>\n                    \u2010Gal\u2010induced liver injury via enhancing the inflammation and the apoptosis in the liver.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22372","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T04:06:05Z","timestamp":1563854765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["\u03b2\u2010Hydroxybutyrate exacerbates lipopolysaccharide\/\n                    <scp>d<\/scp>\n                    \u2010galactosamine\u2010induced inflammatory response and hepatocyte apoptosis in mice"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-8309","authenticated-orcid":false,"given":"Yongqiang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Chongqing Medical University  1 Yixueyuan 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