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Nevertheless, the toxic impact of NiO\u2010NPs has not been clearly elucidated on human melanoma cell lines at the cellular and molecular level. Hence, this study was designed to examine the in vitro cytotoxicity potentials of NiO\u2010NPs on malignant cutaneous melanoma (MCM) mitochondria. Results revealed that NiO\u2010NPs significantly increased reactive oxygen species level, lipid peroxidation, and mitochondrial membrane potential and decreased succinate dehydrogenase activity, glutathione level, and ATP content on skin mitochondria isolated from the mouse model of melanoma compared with the non\u2010cancerous mouse skin mitochondria. Our results revealed that NiO\u2010NPs induced lysosomal membrane labialization on mentioned mitochondria. The current study showed that NiO\u2010NPs could significantly induce selective cytotoxicity on MCM mitochondria. Therefore, this compound may be considered as a promising candidate for further in vivo and clinical studies to reach a new anti\u2010MCM drug.<\/jats:p>","DOI":"10.1002\/jbt.22376","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T01:33:59Z","timestamp":1563759239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma"],"prefix":"10.1002","volume":"33","author":[{"given":"Shabnam","family":"Rahimi","sequence":"first","affiliation":[{"name":"Department of Toxicology &amp; Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch Islamic Azad University (IAUPS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaneh","family":"Naserzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Students Research Committee, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Department of Toxicology &amp; Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch Islamic Azad University (IAUPS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh","family":"Ashtari","sequence":"additional","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Sciences  Tehran Iran"},{"name":"Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enayatollah","family":"Seydi","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Engineering, School of Health Alborz University of Medical Sciences  Karaj Iran"},{"name":"Research Center for Health, Safety and Environment Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-6398","authenticated-orcid":false,"given":"Jalal","family":"Pourahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6288"},{"key":"e_1_2_8_1_3_1","first-page":"5309","volume":"35","author":"Provinciali M.","year":"2015","journal-title":"Anticancer Res."},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.2.421"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.02.011"},{"key":"e_1_2_8_1_6_1","first-page":"1610","volume":"5","author":"Cai T.","year":"2015","journal-title":"Am. 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